Volumetric dosing

Volumetric dosing involves dissolving a known amount of a substance in a specific volume of liquid, facilitating accurate dosage calculations.

This technique is popular for microdosing psychedelics, allowing one to achieve consistent, controlled doses that would be difficult to measure otherwise. It’s also useful for substances measured in the low-milligram range, where consumer scales may not suffice due to tolerances of around 5 mg.

Microdosing LSD #

My preferred medium is a mix of 90% distilled water and 10% distilled spirits to prevent bacterial growth. It’s crucial to ensure the absence of chlorine in any component as it destroys LSD molecules upon contact. I place LSD blotters directly into this solution and store it in an amber glass bottle wrapped in foil and kept in the refrigerator.

Example #

Suppose you have a 50 mL dropper bottle. You fill it with 45 mL of distilled water and 5 mL of triple-distilled vodka, measuring the liquids with a graduated syringe for accuracy. You then add two blotters, each containing 250 mcg of LSD.

This results in a total of 500 mcg of LSD distributed throughout the 50 mL of liquid, equating to 10 mcg per mL. Each full dropper (approximately 1 mL) will deliver a 10 mcg microdose of LSD.

Dosing 4-AcO-DMT #

For substances like 4-Aco-DMT, my preferred solvent is propylene glycol. It inhibits bacterial growth on its own, simplifying the process. The resulting solution is considerably stable and doesn’t require refrigeration. I store it in an amber glass bottle, which helps protect the substance from light.

Example #

Suppose you have a 50 mL dropper bottle. You fill it with 40 mL of propylene glycol, measured using a graduated syringe. You then add 400 mg of 4-AcO-DMT into this solvent.

This yields a solution where the concentration is 400 mg of 4-AcO-DMT per 40 mL of propylene glycol, or 10 mg per mL. Each full dropper (approximately 1 mL) will provide a 10-mg dose of 4-AcO-DMT. If a stronger dose is desired, 1.5 mL can be taken to achieve a 15 mg dose.

Additional considerations #

Measurement #

Accurate measurement is crucial in volumetric dosing to ensure consistency. Graduated syringes are vital tools for measuring both the solvents and the solutions accurately.

While droppers are convenient for administration, their volume can vary slightly between uses. Using a graduated syringe to measure out your doses from the prepared solutions ensures that each dose is as accurate as the initial solvent measurement.

This is particularly important when dealing with potent substances where small discrepancies can lead to significantly different effects.

Labelling #

Finally, always label your bottles clearly with the substance name, concentration, and date of preparation.

This practice helps avoid any confusion or accidental misuse, especially when storing multiple different solutions.